Alignment dependent generic features (Insert | Feature | Generic) have values that depend on the alignment from which they are referenced. They change so that they are always relative to the current alignment. Their location is constant in 3D space.
For an example in 2D, suppose 0,0 is your machine origin. An alignment is set up that locates the origin at 5,5. Now, an alignment dependent feature is defined after the alignment with the values of 2 for x and 2 for y. Relative to the alignment, its values are 2 and 2. Relative to the origin, its values are 7 and 7. No matter what alignment the numbers are given relative to, the point will always be located at 7,7 relative to the true origin.